Summary
The aim of this study was to assess longitudinally cognitive functioning in people with relapsing-remitting multiple sclerosis (RRMS) and its relationship with clinical and MRI variables. Amato MP, Portaccio E, Goretti B, Zipoli V, Iudice A, Della Pina D, Malentacchi G, Sabatini S, Annunziata P, Falcini M, Mazzoni M, Mortilla M, Fonda C, De Stefano N. Mult Scler. 2010 Aug 20. [Epub ahead of print]
Details
Early RRMS patients and matched healthy controls were assessed in
parallel in three testing sessions over 3 years, using a specific
battery of neuropsychological tests. They also underwent an MRI
analysis.
At baseline, cognitive impairment was detected in 15 patients
(30.6%). After 3 years, cognitive functioning worsened in 29.3%
of patients, whereas Expanded Disability Status Scale (EDSS)
progression was observed in only three patients. The most
sensitive test to detect cognitive deterioration over time was
the Symbol Digit Modalities Test (SDMT). Only the presence of
moderate cognitive impairment at baseline predicted further
cognitive deterioration (p = 0.03). Among MRI variables, T2LV
showed a weak to moderate relationship with some cognitive
tasks.
The authors concluded that a cognitive deterioration could be
expected in approximately one-third of MS patients with
relatively short disease duration.